Scientific Videos
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The Application of Novel Imaging Methods to New Drug Development Bruce J. Hillman, M.D. Chief Scientific Officer, ACR Image Metrix™ Medical imaging is a powerful tool that is increasingly being employed in all phases of new drug development, from pre-clinical testing to advanced clinical trials. The purposes of using imaging methods in trials are several fold. Bruce J. Hillman, M.D., explains the application of novel imaging methods to new drug development. |
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Positron Emission Tomography in Drug Development Barry A. Siegel, M.D. Professor of Radiology and Medicine, Washington University School of Medicine PET is widely recognized as the paradigm of molecular imaging. Over the last decade, PET has emerged from its previously limited role as a research tool into a widely used clinical method, most notably for imaging of cancer, as well as for various neurological disorders. Barry A. Siegel, M.D., explains the use of Positron Emission Tomography in drug development. |
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Dynamic Contrast-Enhanced MRI (DCE-MRI) in Drug Development Mark A. Rosen, M.D., Ph.D. Assistant Professor of Radiology, University of Pennsylvania Medical Center Many clinical studies have demonstrated the efficacy of this technique for tumor vascular evaluation during vascular-targeted therapy. DCE-MRI can be useful in Phase I and early Phase II studies. Mark A. Rosen, M.D., Ph.D., explains how DCE-MRI can be employed in new drug development. |
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Magnetic Resonance Spectroscopy (MRS) for Measurement of Hepatic Fat Harish Poptani, Ph.D. Research Associate Professor of Radiology Magnetic Resonance Spectroscopy (MRS) provides biochemical information about biologic tissues. The technique is very much similar to MRI and can be performed on most clinical MRI machines. MRS uses minute differences in the magnetic properties of different chemical compounds to provide a unique biochemical signature for a specific type of tissue. Harish Poptani, Ph.D., presents his ideas on applying MRS to benefit new drug development. |
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A CRO’s Challenge: Validating Leading-Edge Software for Imaging Clinical Studies Conducting imaging in clinical trials often involves the use of cutting-edge computer software. The computer systems featured in the medical imaging workstations used in clinical investigations must be validated prior to data collection in support of a regulatory submission. Brenda K. Young, B.A., CRA, outlines ACR Image Metrix’ approach to the challenge of computer system validation on workstations and software for clinical trials in pursuit of installation qualification and performance qualification, the two key aspects of validation. |
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Quantitative Imaging in Pharmaceutical Discovery and Development Until now, clinical radiology has been composed of a radiologist’s review of imagery, being undertaken with a variety of conditions, but interpreted essentially the same way, which is for the reviewer to visually evaluate the image. However, an increasing number of quantitative analysis approaches have been pursued that create objective and quantitative readouts, which range from morphological to functional measurements. In general, quantitative imaging may be used to efficiently evaluate whether an experimental therapy is effective. Andrew Buckler, MS, discusses the growing role of quantitative imaging in pharmaceutical discovery and development. |
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