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IMAGING CORE LABORATORIES
Predictive Biomarkers
The use of imaging as a predictive biomarker is proving to be successful
in all stages of drug development.
ACR Image Metrix provides you with access to the most experienced
network of imaging researchers. We have over 180 research sites in the
American College of Radiology Imaging Network (ACRIN), upon which ACR
Image Metrix is based. Our team of physicians and scientists partner
with you to identify the appropriate imaging modality that best
addresses the development demands of their specific therapeutic category
and drug.
This usage of imaging as a predictive or prognostic biomarker has
numerous applications, including:
- Phase I/II trials for early assessment of efficacy
- Phase II trials in conjunction with conventional anatomical measures
- Correlative trials with histopathological and genomic data
- Adaptive trials to assign subjects to treatment arms
The Technological Advantage: CT, MRI/MRS & PET Imaging
The ACR Image Metrix core laboratories are equipped with
state-of-the-art technologies that allow us to work across vendor
platforms for such key modalities as CT, MRI/MRS and PET. We provide
both conventional and novel image quantitation, including
two-dimensional, volumetric, and functional/metabolic approaches.
Central reading areas and on-site workstations are interconnected by
TRIAD OA, which is a unified solution encompassing image collection,
transfer, anonymization, re-identification, archiving and viewing of
images.
Our system allows for enhanced annotation and markup utilities while
providing flexible search and download capabilities. Built on years of
experience collecting DICOM images in support of ACRIN clinical trials,
TRIAD OA is designed to be fully interfaceable with major federal
informatics initiatives (e.g., Cancer Biomedical Informatics Grid,
caBIG).
Interpretation and Quantitation
We have developed standard operating processes and procedures to ensure
the normalization of quantitative data across vendors and platforms.
Additionally, ACR Image Metrix is collaborating with the various
regulatory agencies (NCI, FDA and CMS) to develop standards for imaging
acquisition, data normalization, data extraction and the assessment of
variability for such key functional and molecular imaging methods as
PET, DCE-MRI and MRS among others.
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